Diabetes Medicines
Diabetes
Diabetes
mellitus (DM) is a group of metabolic diseases in which there is high blood
sugar due to insufficient insulin production or, in some cases, an absence of
insulin secretion. Diabetes treatment refers to the measures aimed at
normalizing blood glucose levels. Type 1 diabetes, also known as juvenile-onset
diabetes or insulin-dependent diabetes (IDDM) is an autoimmune condition
characterized by rapid onset (onset usually before age 40), hypoalbuminemia,
hyperglycemia, and loss of pancreatic insulin secretion leading to
ketoacidosis. Type 2 diabetes mainly develops from permanent changes in body
fat stores rather than altered responses to insulin released from pancreatic
beta cells after eating carbohydrate-containing foods.
Causes of diabetes
The most common causes of diabetes are:
1. Type 1 diabetes (insulin-dependent diabetes)
2. Type 2 diabetes (non-insulin-dependent
diabetes)
3. Gestational diabetes, which is temporary and
usually disappears after the baby is born and the placenta is delivered.
4. Diabetes occurs as a complication of another
disease, including chronic pancreatitis, hypothyroidism, or a hormonal disorder
such as polycystic ovarian syndrome (PCOS).
Signs and Symptoms of diabetes
The signs and symptoms of diabetes vary
depending on the type of diabetes. The most common type of diabetes is called
Type 2, which is associated with obesity and physical inactivity.
Signs and symptoms of diabetes
The following are some of the more common
symptoms of diabetes:
Nausea or vomiting
Fatigue or weakness
Extreme thirst
Urination problems (especially at night)
Diarrhea or constipation.
Risk Factors of Diabetes
Here are some risk factors that can contribute
to diabetes:
Being overweight or obese. This is the most
important risk factor for developing Type 2 diabetes. Being overweight or obese
increases your chances of developing diabetes by about 50%. Being underweight
does not increase your chances of developing diabetes, but it does make it more
likely that you will have complications from the disease.
Having a family history of Type 2 diabetes and
other metabolic disorders such as gestational diabetes (pregnancy-induced) or
non-insulin dependent diabetes mellitus (NIDDM). There is a higher risk of type
2 diabetes among people with a parent, brother, or sister who has had the
disease.
Excess body weight (obesity). Being overweight
increases your chances of developing type 2 diabetes by about 50%. Being
underweight does not increase your chances of developing type 2 diabetes, but
it does make it more likely that you will have complications from the disease.
People who are overweight also tend to have high blood pressure and high blood
cholesterol levels. Having both high blood pressure and high cholesterol
reduces insulin effectiveness and makes you more likely to develop heart
disease or stroke.
The treatments for diabetes
Treatments
for diabetes are available at many different levels. There are pills and
injections that can be taken by mouth, insulin shots that must be given by
needle, and insulin pumps that deliver the drugs to the body.
Pills
Long-acting
insulins, also called basal or regular, are injected once a day or less often
at night. Examples include NPH and Lantus. You may have to adjust your dose to
achieve good control. You will continue to need these medications even when you
stop using insulin pumps because they work only when they are being delivered
through an artificial pancreas.
Insulin
multiple daily injections (MDI) is an older type of insulin preparation used to
treat people with type 1 diabetes who require frequent injections of
rapid-acting insulin throughout the day. It is no longer used in adults as a
treatment for type 1 diabetes; however, it is still prescribed for type 1
diabetes in children and adolescents whose body weight has not stabilized. This
drug is administered by injection under the skin (subcutaneously) once daily or
less frequently (every two days).
Pump
therapy
The
pump is a small, battery-operated device that delivers insulin through a
catheter inserted into a vein. It can administer insulin to people who cannot
use needles or people who cannot take insulin by mouth.
Pumps
are particularly useful for people with diabetes whose eyesight may be impaired
by the effects of high blood glucose levels, who may have difficulty reading
the dosage information on the syringe, or who find it difficult to draw up
insulin from bags.
Pumps
also provide flexibility in treatment schedules and avoid the inconvenience of
having to change daily glucose testing sites or test at certain times of the
day. This makes it easier for people with diabetes to regulate their blood
sugar levels if they have trouble controlling them with diet and exercise
alone.
The
treatments for diabetes are:
*1.
Diet and exercise
*2.
Insulin and other medications
*3.
Topical agents
*4.
Surgery and other procedures
Diet and exercise
Diabetes
can be controlled by diet and exercise.
Dietary
changes alone may not be sufficient for all people with diabetes. However, diet
and exercise can help you control your blood sugar level.
A
healthy diet includes protein, carbohydrates, and fat at each meal. You should
also limit foods that are high in sugars, fats, salt, and calories.
You
may need to change your eating habits if you have diabetes. Your doctor or
dietitian may suggest that you eat meals at regular times each day so that you
get enough calories throughout the day. If you're overweight or obese, your
doctor may also suggest limiting foods that are high in fats, sugars, and
cholesterol in order to lower your calorie intake. In addition, you may want to
limit the number of sugary drinks such as soda pop or fruit juices you drink
each day because they contain lots of sugar.
You
should start slowly when making changes to your eating habits. Try making small
changes over time instead of trying to change everything overnight.
Exercise
is an important part of managing diabetes because it helps keep your blood
sugar levels stable by increasing insulin production in the pancreas (insulin
secretion).
Insulin and other medications
Insulin
and other medications' role in diabetes treatment
The
most common way to lower blood sugar levels is with the injection of insulin.
Other medications may be needed if insulin injections do not work well enough
or if they cause too many side effects.
Insulin,
a hormone made in the pancreas, helps glucose move from your bloodstream into
your cells where it is used for energy. Insulin can be given by injection
(pump) or infusion (by vein).
Injections
are delivered through a needle inserted into a vein in your arm or leg. Insulin
comes in several different strengths and types, so you will be matched to the
dose that works best for you. Insulin generally works best when injected into
muscles rather than fat tissue because it does not penetrate very far into fat
cells.
Insulin
comes as:
Insulin
glargine (Lantus®) - a rapid-acting insulin taken by injection once daily at
bedtime to mimic the natural production of insulin throughout the day;
available only through a special program called Pathway to Prevention®; may
also be used before meals in people with type 2 diabetes who cannot take oral
diabetes medicines (sulfonylureas), or as an additional long-acting injectable
medicine added to pump.
Topical agents
Topical
agent's role in diabetes treatment
Topical
agents are used to treat skin conditions like acne, eczema, and psoriasis.
Topical agents are also used for anti-aging, anti-wrinkle, and
anti-inflammatory properties. Topical agents can be applied directly on the
skin or taken orally.
Topical
agents are used to treat hyperglycemia and hypoglycemia. Topical agents may be
prescribed for people with diabetes who have difficulty controlling their blood
sugar. For example, if a person has diabetes but does not take insulin
properly, or does not take enough insulin, oral medications alone may be
ineffective in preventing the onset of high blood sugar levels. In such cases,
topical agents can be prescribed to help control blood sugar levels by reducing
glucose absorption through the skin when applied topically.
Topical
agents may also be prescribed in conjunction with insulin administration to
reduce the risk of low blood sugar levels occurring while taking oral
medications with time-release formulations (e.g., fast-acting insulins) or when
taking oral medications that require frequent dosing intervals (e.g.,
intermediate-acting insulins).
Surgery and other procedures
Surgery
and other procedures' role in diabetes treatment
Many
people with diabetes require surgery or other procedures, including
angioplasty, bypass surgery, and dialysis. These procedures are generally safe
and effective when performed by experienced surgeons. However, complications
can occur. For example:
Angioplasty
-- The goal of angioplasty is to open narrowed arteries so blood flow can be
restored to the heart. This procedure may be done as an outpatient procedure or
as an inpatient procedure under general anesthesia. If performed as a
day-surgery procedure, you will be given medication to help you relax before
the procedure. You will then be put under anesthesia for about 2 hours and then
wake up to find your doctor standing next to you.
Bypass
surgery -- Bypass surgery refers to procedures that remove part of the
circulatory system from the body (artery) of a patient with diabetes so that
blood flow through these arteries is not affected by severe atherosclerosis.
Bypass surgery may be done either as an outpatient procedure or an inpatient
procedure under general anesthesia or regional anesthesia (narcotic drugs).
The types of medicines for type 1 diabetes
Medicines
for type 1 diabetes are usually given as tablets, capsules, or a drink.
Your doctor may decide that you need to take more than one medicine at a time, or they may suggest a combination of medicines.
Some
types of medicine are taken by mouth (by mouth), while others are given by
injection (intravenous). Some medicines are given as drops into the eye
(ophthalmic).
Most
people with type 1 diabetes start with one medicine at first, but some do not
have any problems and do not need it at all. You may be able to stop taking
your medicine after 3 months if you feel better without it; however, this does
not always happen because some people still have symptoms despite being on
medication for 2 years or more.
The types of medicines for type 2 diabetes
There
are two types of medicines to treat type 2 diabetes: oral medications and
insulin.
Oral
medications are taken by mouth. They include:
sulfonylurea
(e.g., glyburide, glipizide)
metformin
(e.g., Glucophage)
troglitazone
(e.g., Rebetol)
other
drugs that lower blood glucose levels (e.g., pioglitazone [Actos],
rosiglitazone [Avandia])
Some
people with diabetes are able to manage their condition without taking any
medicines. But others may need medicines to help control their blood glucose
levels or blood sugar.
Medicines
can help you to live with type 2 diabetes and lower your risk of complications.
Medicines are available in many different forms: tablets, capsules, liquids,
and gels. They come as fixed dose combinations (FDCs) or a combination of
tablets and FDCs.
You
may be prescribed medicines to help control your blood glucose levels. You will
often be advised to take these for the rest of your life. However, if you stop
taking them suddenly, you could have some unpleasant side effects such as
dizziness or feeling sick.
There
are two main types of medicine for type 2 diabetes:
Sulfonylureas
– sulphonyl urea (brand name Sulzem®, Sulfonylurea Zarsenil®) and glimepiride
(brand name Gliklizide®) work by making the liver produce more insulin after
eating food which has been converted into glucose by the digestive system.
These are taken once a day at the same time each day.
The types of medicines for type 3 diabetes
There are many different types of medicines for
type 3 diabetes, such as oral medications and insulin. Some people may have to
take multiple medicines.
Oral medicines
Oral medicines are taken by mouth. They are
available in many forms and vary according to the patient's specific needs.
Oral medicines help control blood sugar levels by:
Reducing insulin use when you eat more
carbohydrates than your body can use (such as a sugary snack). This reduces the
amount of glucose in your blood, which helps prevent too much sugar from being
absorbed into your bloodstream.
Controlling high blood sugar (hyperglycemia) by
helping the body produce less insulin after eating a meal or snack containing
carbohydrates. As a result, less glucose is absorbed into the bloodstream,
lowering your blood sugar level.
Stopping the absorption of some sugars by
blocking their action on cells that respond to them (sugar receptors).
The types of medicines for type 4 diabetes
The types of medicines for type 4 diabetes
The two main types of medicines used to treat
type 2 diabetes are:
a) Oral hypoglycaemic agents, which include:
1. Succinate dextrose (glucose) tablets
(sugar-free)
2. Fruity glucose tablets (glucose)
3. Fruity sucrine tablets (carbohydrate-rich)
4. Sulfonylurea tablets (glucose-regulating)
5. Glibenclamide (metformin) or glimepiride
(metformin).
b) Insulin: subcutaneous injection or infusion.
The types of medicines for type 4 diabetes:
1. Oral hypoglycaemic agents (such as
sulfonylureas) - These include tolbutamide, chlorpropamide, and glibenclamide.
They work by lowering the amount of sugar in your blood by forcing your body to
use it as energy.
2. Insulin - This is a hormone that helps you to use glucose (sugar) from food and drink. You inject different types of insulin depending on whether you are eating or drinking.
Conclusion
Diabetes is a
chronic disease of blood sugar characterized by hyperglycemia resulting
from defects in insulin secretion, its action, or both; it is not a single
disease but a cluster of closely related disorders.
Diabetes is a
chronic, non-communicable disease. This makes it a lifestyle disease. It occurs
when the pancreas does not produce insulin hormone or when the body loses its
ability to use insulin effectively. This can make it difficult for your body to
get energy from food. Diabetes is a group of diseases that cause elevated
levels of blood glucose (also called blood sugar). It can be very serious and
even life-threatening if not well controlled. Type 1 diabetes is characterized
by low levels of insulin production by the pancreas, and type 2 diabetes is
characterized by insufficient response by cells in the body to insulin given by
pancreas.
Humans
have been able to cure diabetes naturally with natural remedies, diet or herbs.
The above information was for medical use, but it is not to replace the advice
given by a doctor or qualified health professional. We recommend that you seek
advice from a qualified health professional before making any changes to your
diet or lifestyle and whilst taking any supplements. Also check out this site
on natural cures for cancer.
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