Which of the following NSAIDs
inhibits COX-1 more potently than COX-2
a) Flurbiprofen
b) Indomethacin
c) Diclofenac
d) Celecoxib
Answer:
Flurbiprofen
Flurbiprofen
Flurbiprofen has greater inhibitory selectivity
for COX-1 than COX-2. Flurbiprofen is a nonselective NSAID that causes
gastrointestinal damage.
Flurbiprofen is a non-steroidal anti-inflammatory
drug (NSAID) that acts on the cyclooxygenase (COX) enzyme, which is involved in
the synthesis of prostaglandins. It inhibits the production of prostaglandins
in the body and thus reduces inflammation. Flurbiprofen also has anti-platelet
activity, which helps prevent blood clots from forming.
Flurbiprofen is chemically similar to naproxen
and diclofenac. Naproxen and diclofenac have greater inhibitory selectivity for
COX-1 than COX-2, while ibuprofen has moderate selectivity.
Flurbiprofen uses
Flurbiprofen is used to treat osteoarthritis,
rheumatoid arthritis, and other forms of arthritis. Flurbiprofen relieves pain
and inflammation in the joints by reducing the activity of certain enzymes that
can be involved in inflammation.
For More MCQs:
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